PLASMOCITOMA PDF

Risk factors The main risk factors for this disease were identified: Elderly men and middle-aged men - plamocytoma begins to develop when the amount of male hormone testosterone in the body decreases. People with excess weight - with obesity, there is a decrease in metabolism, which can lead to the development of this disease. Irradiation with radioactive substances. A single plasmacytoma of the bone arises from plasma cells located in the bone marrow, while the extramedullary plasmacytoma is believed to arise from plasma cells located on the mucous membranes. Both variants of the disease are different groups of neoplasms in terms of location, tumor progression and overall survival.

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Back pain and other consequences of the bone lesion may occur such as spinal cord compression or pathological fracture. In some tissues it may be found as a palpable mass. The diagnosis of plasmacytoma uses a diverse range of interdisciplinary techniques including serum protein electrophoresis , bone marrow biopsy , urine analysis for Bence Jones protein and complete blood count , plain film radiography , MRI and PET-CT.

Normal blood serum contains a range of antibodies and are said to be polyclonal , whereas serum from a person with plasmacytoma may show a monoclonal spike. This is due to an outgrowth of a single type of plasma cell that forms the plasmacytoma and produces a single type of antibody. The plasma cells are said to be monoclonal and the excessively produced antibody is known as monoclonal protein or paraprotein. Tissue biopsies of SPB and extramedullary plasmacytoma are used to assess the phenotype of the plasma cells.

Histological analyses can be performed on these biopsies to see what cluster of differentiation CD markers are present and to assess monoclonality of the cells. CD markers can aid in the distinction of extramedullary plasmacytoma from lymphomas. MRI can be used to assess tumor status and may be advantageous in detecting primary tumors that are not detected by plain film radiography. CT imaging may be better than plain film radiography for assessing bone damage.

The difference between plasmacytoma and multiple myeloma is that plasmacytoma lacks increased blood calcium , decreased kidney function , too few red blood cells in the bloodstream, and multiple bone lesions collectively termed CRAB. Plasmacytoma is a tumor of plasma cells. The cells are identical to those seen in multiple myeloma , but they form discrete masses of cells in the skeleton solitary plasmacytoma of bone; SPB or in soft tissues extramedullary plasmacytoma; EP.

They do not present with systemic disease , which would classify them as another systemic plasma cell disorder. The criteria for extramedullary plasmacytoma are the same but the tumor is located in soft tissue.

No bone lesions should be present. They may occur as multiple primary tumors or as a recurrence from a previous plasmacytoma. Association with the Epstein—Barr virus[ edit ] Rarely, the Epstein—Barr virus EBV is associated with multiple myeloma and plasmacytomas, particularly in individuals who have an immunodeficiency due to e.

EBV-positivity is more common in plasmacytoma than multiple myeloma. EBV-positive plasmacytoma s is more likely to progress to multiple myeloma than EBV-negative plasmacytoma s suggesting that the virus may play a role in the progression of plasmacytoma to multiple myeloma.

This form of treatment can be used with curative intent because plasmacytoma is a radiosensitive tumor. Surgery is an option for extramedullary plasmacytoma, but for cosmetic reasons it is generally used when the lesion is not present within the head and neck region.

The median age at diagnosis for all plasmacytomas is Both SPB and extramedullary plasmacytoma are more prevalent in males; with a male to female ratio for SPB and a ratio for extramedullary plasmacytoma.

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Plasmocitoma

Le cause plasmocitoma I medici non hanno ancora capito esattamente cosa causa la mutilazione dei linfociti B nelle cellule mielomatose. Irradiazione con sostanze radioattive. Entrambe le varianti della malattia sono diversi gruppi di neoplasie in termini di localizzazione, progressione tumorale e sopravvivenza globale. I sintomi principali dipendono dallo stadio della malattia.

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Plasmocitoma: definición, síntomas, tratamiento y mucho más

Llamadas plasmocitos. Su tarea fundamental es producir los. El estadio de la enfermedad jugara un papel, la edad del paciente y las posibles comorbilidades. La etapa alta de Plasmocitoma. La gran edad.

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Plasmacytoma

Quando rivolgersi al medico? B: alla luce di quanto detto precedentemente, nella maggior parte dei casi, il plasmocitoma solitario extramidollare produce questi sintomi. Servono a chiarire la sintomatologia e lo stato di salute generale del paziente. Sono fondamentali per capire con quali altre indagini proseguire la ricerca diagnostica. Un esame del sangue chiamato elettroforesi sieroproteica.

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Plasmocitoma: Cos'è? Cause, Sintomi, Diagnosi, Terapia e Prognosi

Back pain and other consequences of the bone lesion may occur such as spinal cord compression or pathological fracture. In some tissues it may be found as a palpable mass. The diagnosis of plasmacytoma uses a diverse range of interdisciplinary techniques including serum protein electrophoresis , bone marrow biopsy , urine analysis for Bence Jones protein and complete blood count , plain film radiography , MRI and PET-CT. Normal blood serum contains a range of antibodies and are said to be polyclonal , whereas serum from a person with plasmacytoma may show a monoclonal spike. This is due to an outgrowth of a single type of plasma cell that forms the plasmacytoma and produces a single type of antibody. The plasma cells are said to be monoclonal and the excessively produced antibody is known as monoclonal protein or paraprotein. Tissue biopsies of SPB and extramedullary plasmacytoma are used to assess the phenotype of the plasma cells.

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